FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Schwartzberg Gil
2. Issuer Name and Ticker or Trading Symbol

LIXTE BIOTECHNOLOGY HOLDINGS, INC. [ LIXT.OB ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                      __ X __ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)

269 S. BEVERLY DR., #1315
3. Date of Earliest Transaction (MM/DD/YYYY)

4/2/2014
(Street)

BEVERLY HILLS, CA 90212
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common stock                  750800   D    
Common stock                  829782   D    
Common stock                  558815   I   Continuum Capital Partners, L.P.   (1)
Common stock                  1150000   I   David Stirling Trust   (2)
Common stock                  1184000   I   Julie Schwartzberg Trust   (3)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Warrants   (4) $0.750   4/2/2014     J         500000    1/20/2010   6/30/2014   Common   500000   $0   0   D    
Warrants   (5) $0.750   4/2/2014     J         500000    1/20/2010   6/30/2014   Common   500000   $0   0   I   Julie Schwartzberg Trust  
Warrants   (6) $0.750   4/2/2014     J         500000    1/20/2010   6/30/2014   Common   500000   $0   0   I   David Stirling Trust  
Options   $1.00                    10/15/2009   10/15/2014   Common   500000     500000   D    
Options   $1.00                    10/5/2011   10/15/2016   Common   500000     500000   D    
Options   $1.00                    9/11/2012   9/11/2017   Common   500000     500000   D    
Options   $0.50                    1/28/2014   1/28/2019   Common   2000000     2000000   D    

Explanation of Responses:
( 1)  Owned by Continuum Capital Partners, L.P. as to which Mr. Schwartzberg has sole voting, disposition and investment control.
( 2)  Owned by the David Stirling Trust as to which Mr. Schwartzberg is the Co-Trustee.
( 3)  Owned by the Julie Schwartzberg Trust as to which Mr. Schwartzberg is the Co-Trustee.
( 4)  Consists of warrants owned by Mr. Schwartzberg which were assigned without consideration to unrelated parties who subsequently exercised the warrants.
( 5)  Consists of warrants owned by the Julie Schwartzberg Trust which were assigned without consideration to an unrelated party who subsequently exercised the warrants.
( 6)  Consists of warrants owned by the David Stirling Trust which were assigned without consideration to an unrelated party who subsequently exercised the warrants.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Schwartzberg Gil
269 S. BEVERLY DR.
#1315
BEVERLY HILLS, CA 90212

X


Signatures
/s/ Gil Schwartzberg 5/14/2014
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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