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                                                             March 24, 2025

Jeffrey Frelick
Chief Executive Officer
Bone Biologics Corp
2 Burlington Woods Drive, Suite 100
Burlington, MA 01803

        Re: Bone Biologics Corp
            Draft Registration Statement on Form S-1
            Submitted March 17, 2025
            CIK No. 0001419554
Dear Jeffrey Frelick:

        This is to advise you that we do not intend to review your registration
statement.

       We request that you publicly file your registration statement at least
two business
days prior to the requested effective date and time. Please refer to Rules 460
and 461
regarding requests for acceleration. We remind you that the company and its
management are
responsible for the accuracy and adequacy of their disclosures, notwithstanding
any review,
comments, action or absence of action by the staff.

        Please contact Margaret Sawicki at 202-551-7153 with any questions.


                                                             Sincerely,

                                                             Division of
Corporation Finance
                                                             Office of
Industrial Applications and
                                                             Services
cc:    Alexander R. McClean, Esq.
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